DNA points are the currency a player uses during the Cell Stage and the Creature Stage to purchase different body parts for their creature (eyes, ears, limbs, accessories, etc) while in the Cell Editor or Creature Editor. DNA points are earned as the player goes through the respective phase and completes certain tasks, such as eating. In the Creature Stage the player may also earn points by having their creature successfully befriending other creatures, engaging in pack/herd behaviour, or by engaging in combat with another creature and defeating it. The player can also gain DNA points by eating other species' eggs for a bonus of 25 to 50 points. Though tough to achieve, Rogue and Epic creatures can be killed, and Rogues befriended, for 100 DNA Points.

When the player is brought to the Cell or Creature Editor, their current amount of DNA points is shown in the lower-left of the screen. Every time a body part is bought or sold, the current funds will decrease or increase accordingly. When selling a part, the player will get a 100% refund on the part, meaning they can sell a few small, inexpensive parts to buy a larger, more expensive part. Because of the way this system works, the player can never truly lose any DNA, because it will always be a part of the creature and available for refunding, as opposed to in the City Editor, or when managing vehicles, whereby if a building or vehicle is sold, only 50% of the initial price in Sporebucks will be refunded.

The Tribal, Civilization and Space Stage equivalents to DNA points are food points and Sporebucks respectively, although the points for clothing, buildings and vehicles in the Outfit, Building and Vehicle Editors resemble them more in purpose.