BIOME was a Spore Prototype made by EA that featured 'sim-city' like grid.
BIOME uses a language based on chemical stoichiometry, the notation system used to describe chemical reactions. Cells in a BIOME simulation change state the same way that chemicals change when exposed to other chemicals.
These Systems can create Forest Fires, disease epidemics, animal migration patterns and crystallization.
You can download this and other prototypes by clicking here:[1]